Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients
Identifieur interne : 000741 ( Main/Exploration ); précédent : 000740; suivant : 000742Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients
Auteurs : Gonzalo J. Martínez [Australie, Chili] ; Jennifer Y. Barraclough [Australie] ; Shirley Nakhla [Australie] ; Vivian Kienzle [Australie] ; Stacy Robertson [Australie] ; Ziad Mallat [France, Royaume-Uni] ; David S. Celermajer [Australie] ; Sanjay Patel [Australie]Source :
- Bioscience Reports [ 0144-8463 ] ; 2017.
Abstract
To evaluate (i) local coronary and systemic levels of microparticles (MP) in acute coronary syndrome (ACS) and stable angina pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary intervention (PCI). MP are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilization and shed neutrophil-derived MP that have the potential to drive significant proinflammatory and thrombotic downstream effects. Eight ACS and eight SAP patients were included. Coronary sinus (CS) samples pre-intervention (CS1), 45 s following balloon angioplasty (CS2) and at 45 s intervals following stent deployment (CS3, CS4 and CS5), together with peripheral vein samples, pre- and post-PCI were analysed for neutrophil-derived (CD66b+), endothelial-derived (CD144+), platelet-derived (CD41a+), monocyte-derived (CD14+) and apoptotic (Annexin V+) MP. ELISA for interleukin (IL)-6, myeloperoxidase (MPO) and P-selectin was also performed. CD66b+ MP levels were similar in both groups pre-intervention. Post-PCI, CS levels rose significantly in ACS but not SAP patients (ACS area under the curve (AUC): 549 ± 83, SAP AUC: 24 ± 29,
Url:
DOI: 10.1042/BSR20160430
PubMed: 27913753
PubMed Central: 5240586
Affiliations:
- Australie, Chili, France, Royaume-Uni
- Angleterre, Angleterre de l'Est, Nouvelle-Galles du Sud, Île-de-France
- Cambridge, Paris, Sydney
- Université de Cambridge, Université de Sydney
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>To evaluate (i) local coronary and systemic levels of microparticles (MP) in acute coronary syndrome (ACS) and stable angina pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary intervention (PCI). MP are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilization and shed neutrophil-derived MP that have the potential to drive significant proinflammatory and thrombotic downstream effects. Eight ACS and eight SAP patients were included. Coronary sinus (CS) samples pre-intervention (CS1), 45 s following balloon angioplasty (CS2) and at 45 s intervals following stent deployment (CS3, CS4 and CS5), together with peripheral vein samples, pre- and post-PCI were analysed for neutrophil-derived (CD66b+), endothelial-derived (CD144+), platelet-derived (CD41a+), monocyte-derived (CD14+) and apoptotic (Annexin V+) MP. ELISA for interleukin (IL)-6, myeloperoxidase (MPO) and P-selectin was also performed. CD66b+ MP levels were similar in both groups pre-intervention. Post-PCI, CS levels rose significantly in ACS but not SAP patients (ACS area under the curve (AUC): 549 ± 83, SAP AUC: 24 ± 29, <italic>P</italic>
<0.01). CS CD41a+, CD144+, CD14+ and Annexin V+ MP levels did not differ between groups. Acute neutrophil-derived MP release post-PCI occurs in ACS compared with stable patients, likely to be reflective of plaque MP content in vulnerable lesions.</p>
</div>
</front>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Chironi, G" uniqKey="Chironi G">G. Chironi</name>
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<li>France</li>
<li>Royaume-Uni</li>
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<li>Angleterre de l'Est</li>
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<li>Île-de-France</li>
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<li>Paris</li>
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<name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name>
<name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name>
<name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name>
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<country name="Chili"><noRegion><name sortKey="Martinez, Gonzalo J" sort="Martinez, Gonzalo J" uniqKey="Martinez G" first="Gonzalo J." last="Martínez">Gonzalo J. Martínez</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name>
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